Founded in 1994, the Max Planck Institute for the History of Science (MPIWG) in Berlin is one of the more than 80 research institutes of the Max Planck Society. Since its inception, the Institute has continually expanded the boundaries of the field of the history of science—critically interrogating basic concepts, bringing multiple disciplines into dialogue, and experimenting with novel research methods. Research at the Institute investigates how knowledge is produced, circulated, and transformed across time and place. We study the practices, institutions, and infrastructures through which scientific inquiry takes shape, and how scientific, technological, and medical practices both respond to—and in turn refashion— the social, political, and material orders in which they operate. Our research addresses the history of knowledge in its global diversity and across the full span of human history, with specific areas of focus determined by the research agendas of the Institute’s departments (“Knowledge Systems and Collective Life” and “Artifacts, Action, Knowledge”) and research groups. The Institute also engages with pressing issues related to scientific and technological practices, exploring their intersections with policy and their impact on society and the environment.